People

Pavimol Angsantikul (Keep), PhD

Pavimol Angsantikul (Keep), PhD

Postdoctoral Fellow
Oral drug delivery is considered a desirable administration route and offers multiple advantages for patients. However, the natural barriers present in the gastrointestinal tract (GI) prompts many challenges for an effective oral delivery. My research focuses on exploiting ionic liquids as a drug carrier for GI delivery application. Particularly, I am interested in the delivery of biological drugs and elucidating their fate in vivo.
Northwest Building, B160
52 Oxford Street
Cambridge, MA 02138
Tyler Brown

Tyler Brown

Graduate Student
Delivering chemotherapeutics, neuroprotective agents, and other drugs to the brain has proven to be a challenging feat, primarily due to the physical yet dynamic blood brain barrier (BBB). My work focuses on developing a human brain-on-a-chip to better assess and help improve upon promising drug delivery technologies for the treatment of neurodegenerative and other brain-related diseases.
Wyss Institute
3 Blackfan Circle, 2nd Floor
Room 206-7A, Center for Life Science
Boston, MA
Alex

Alexander Curreri

Graduate Student
My research focuses on the development of ionic liquid formulations for topical/transdermal delivery of antibodies and other larger protein biologics. I hope to discover formulations that allow for more efficient localized treatments of various skin diseases that have better patient compliance than the current injection methods. 
Northwest Building, B153
52 Oxford Street
Cambridge, MA 02138
Vimisha D

Vimisha Dharamdasani, MS

The objective of my research is to develop a novel ionic-liquid formulation for topical delivery of nucleic acids into the skin. The resulting platform will have broad applications to other nucleic acids for the treatment of a wide range of dermatological conditions. 
Northwest Building, B153
52 Oxford Street
Cambridge, MA 02138
Guo

Junling Guo, PhD

Postdoctoral Fellow
The possibility to exploring the unique physicochemical and biological properties of polyphenols can serve as an important source of inspiration in the search for new and improved biomaterials. My research focuses on the engineering of cells with polyphenol-functionalized materials or biological molecules to pursue highly challenging biological goals.
Cambridge - Northwest Building, B164, 52 Oxford Street, Cambridge, MA 02138
Longwood - Wyss Institute, 203, 3 Blackfan Cir, Boston, MA 02115
Wei

Wei He, PhD

Biological drugs play an increasingly important role in disease theray, however, their effective delivery is challenging. My research interests predominantly include cytosol delivery of the biopharmaceutics with a drug-delivering-drug (DDD) platform and liposome-assisted (spatial) codelivery of the biologics and small-molecular drugs for combinatorial treatment. Additionally, I am focusing on the translation of several novel formulations and have wide contact with the industry.

Northwest Building, B153
52 Oxford Street
Cambridge, MA 02138
Kelly Ibsen

Kelly Ibsen

Lab Coordinator
My research is focused on the use of ionic liquids in medical applications. For transdermal drug delivery, ILs can enhance penetration of macromolecules like insulin through the skin, alleviating the need for painful injections. ILs also exhibit antimicrobial activity, and are particularly good at disrupting biofilms created by some bacterial species.
Northwest Building, B164
52 Oxford Street
Cambridge, MA 02138
Jay

Jayoung (Jay) Kim

Postdoctoral fellow
My research focuses on engineering ionic liquid as an injectable delivery vehicle. Currently, ionic liquid is used as a transdermal / mucosal permeation enhancer in biomedical applications. However, given a huge library of ionic liquid with a wide range of hydrophobicity and viscosity that can be formulated, I focus on screening and identifying ionic liquids that are biocompatible and dissolve therapeutics (small molecules, biomacromolecules, etc.) for two different applications: 1) provide sustained release following subcutaneous injection or 2) improve penetration through cell membrane. The key is to keep these systems simple and practical for clinical translation.
Northwest Building, B164
52 Oxford Street
Cambridge, MA 02138
VK

Vinu Krishnan, MSE, PhD

Postdoctoral Fellow
My research focuses on developing safe and effective treatments for cancer. I am currently working towards the clinical translation of polymer-drug conjugates for indications in dermatology and oncology. At extremely low doses, these formulations could save lives and improve the quality of life for patients undergoing treatment. I am looking to build strategic alliances with companies, and invite potential investors while identifying new unmet areas in the clinic for these drugs.
Northwest Building, B165
52 Oxford Street
Cambridge, MA 02138
Abhirup

Abhirup Mandal, PhD

Postdoctoral Fellow

The lack of understanding of ionic liquid (IL)-based formulations and drug delivery systems for biomolecules poses a hurdle to their future integration into the pharmaceutical sector. My research focuses on (1) developing a well-defined toolbox of solvent architectures for IL-based formulations; (2) discovering common & complimentary elements for ILs rational design; and (3) finely tuning IL-based platforms for delivering biomolecules across various biological barriers while preserving their biological activity for a prolonged period.

Northwest Building, B158
52 Oxford Street
Cambridge, MA 02138
Prof. Samir Mitragotri

Professor Samir Mitragotri

Principal Investigator
Hiller Professor of Bioengineering and Hansjorg Wyss Professor of Biologically Inspired Engineering
Core Faculty Member, Wyss Institute for Biologically Inspired Engineering
Prof. Mitragotri has made groundbreaking contributions to the field of biological barriers and drug delivery. His research has advanced fundamental understanding of biological barriers and has led to the development of new materials as well as technologies for diagnosis and treatment of various ailments including diabetes, cancer, cardiovascular diseases, skin conditions and infections, among others. Many of his technologies have advanced to human clinical studies and products. At the same time, fundamental understanding developed through his research has advanced the understanding of the biology of barriers in the human body.
211 Pierce Hall
Max

Maksymillan Nowak

Graduate Student

Delivering chemotherapeutics, neuroprotective agents, and other drugs to the brain has proven to be a challenging feat, primarily due to the physical yet dynamic blood brain barrier (BBB). My work focuses on developing a human brain-on-a-chip to better assess and help improve upon promising drug delivery technologies for the treatment of neurodegenerative and other brain-related diseases.

Wyss Institute
3 Blackfan Circle, 2nd Floor
Room 206-7A, Center for Life Science
Boston, MA
Nabi

Md "Nabi" Nurunnabi, PhD

Postdoctoral Fellow

Delivering therapeutics to the right cells of interest at the right time is not only necessary for higher therapeutic efficacy but also for limiting their off-target mediated toxicity. My interest lies on developing bioengineered advanced delivery approach for cell specific drug delivery for treatment of chronic diseases. My research within Mitragotri Lab is focused on oral delivery of large molecules and understanding their biological fate and therapeutic mechanism in cellular level.... Read more about Md "Nabi" Nurunnabi, PhD

Northwest Building, B158
52 Oxford Street
Cambridge, MA 02138