People

Pavimol Angsantikul (Keep), PhD

Pavimol Angsantikul (Keep), PhD

Postdoctoral Fellow
Oral drug delivery is considered a desirable administration route and offers multiple advantages for patients. However, the natural barriers present in the gastrointestinal tract (GI) prompts many challenges for an effective oral delivery. My research focuses on exploiting ionic liquids as a drug carrier for GI delivery application. Particularly, I am interested in the delivery of biological drugs and elucidating their fate in vivo.
Northwest Building, B160
52 Oxford Street
Cambridge, MA 02138
Tyler Brown

Tyler Brown

Graduate Student
Delivering chemotherapeutics, neuroprotective agents, and other drugs to the brain has proven to be a challenging feat, primarily due to the physical yet dynamic blood brain barrier (BBB). My work focuses on developing a human brain-on-a-chip to better assess and help improve upon promising drug delivery technologies for the treatment of neurodegenerative and other brain-related diseases.
Wyss Institute
3 Blackfan Circle, 2nd Floor
Room 206-7A, Center for Life Science
Boston, MA
Alex

Alexander Curreri

Graduate Student
My research focuses on the development of ionic liquid formulations for topical/transdermal delivery of antibodies and other larger protein biologics. I hope to discover formulations that allow for more efficient localized treatments of various skin diseases that have better patient compliance than the current injection methods. 
Northwest Building, B153
52 Oxford Street
Cambridge, MA 02138
Vimisha D

Vimisha Dharamdasani, MS

The objective of my research is to develop a novel ionic-liquid formulation for topical delivery of nucleic acids into the skin. The resulting platform will have broad applications to other nucleic acids for the treatment of a wide range of dermatological conditions. 
Northwest Building, B153
52 Oxford Street
Cambridge, MA 02138
Guo

Junling Guo, PhD

Postdoctoral Fellow
The possibility to exploring the unique physicochemical and biological properties of polyphenols can serve as an important source of inspiration in the search for new and improved biomaterials. My research focuses on the engineering of cells with polyphenol-functionalized materials or biological molecules to pursue highly challenging biological goals.
Cambridge - Northwest Building, B164, 52 Oxford Street, Cambridge, MA 02138
Longwood - Wyss Institute, 203, 3 Blackfan Cir, Boston, MA 02115
Christine Hamadani

Christine Hamadani

Graduate Student

My research focus involves utilizing synthesized designer protein-phobic ionic liquids as polymeric nanoparticle surface capping agents to bypass premature clearance in the bloodstream and maximize bioavailability for targeted chemotherapeutic drug delivery in vivo. 

Northwest Building, B153
52 Oxford Street
Cambridge, MA 02138
Wei

Wei He, PhD

Biological drugs play an increasingly important role in disease theray, however, their effective delivery is challenging. My research interests predominantly include cytosol delivery of the biopharmaceutics with a drug-delivering-drug (DDD) platform and liposome-assisted (spatial) codelivery of the biologics and small-molecular drugs for combinatorial treatment. Additionally, I am focusing on the translation of several novel formulations and have wide contact with the industry.

Northwest Building, B153
52 Oxford Street
Cambridge, MA 02138
Kelly Ibsen

Kelly Ibsen

Lab Manager
My research is focused on the use of ionic liquids in medical applications. For transdermal drug delivery, ILs can enhance penetration of macromolecules like insulin through the skin, alleviating the need for painful injections. ILs also exhibit antimicrobial activity, and are particularly good at disrupting biofilms created by some bacterial species.
Northwest Building, B164
52 Oxford Street
Cambridge, MA 02138
Neha Kapate

Neha Kapate

Graduate Student

I am pursuing a PhD in Medical Engineering and Medical Physics through the Harvard-MIT Health Sciences & Technology program. My research interests involve the development of cell-based therapies to improve drug targeting and accumulation. Supported by the National Science Foundation (NSF) Graduate Research Fellowship.

Northwest Building, B153
52 Oxford Street
Cambridge, MA 02138
Jay

Jayoung (Jay) Kim, PhD

Postdoctoral Fellow
My research focuses on engineering ionic liquid as an injectable delivery vehicle. Currently, ionic liquid is used as a transdermal / mucosal permeation enhancer in biomedical applications. However, given a huge library of ionic liquid with a wide range of hydrophobicity and viscosity that can be formulated, I focus on screening and identifying ionic liquids that are biocompatible and dissolve therapeutics (small molecules, biomacromolecules, etc.) for two different applications: 1) provide sustained release following subcutaneous injection or 2) improve penetration through cell membrane. The key is to keep these systems simple and practical for clinical translation.
Northwest Building, B164
52 Oxford Street
Cambridge, MA 02138
VK

Vinu Krishnan, MSE, PhD

Postdoctoral Fellow
My research focuses on developing safe and effective treatments for cancer. I am currently working towards the clinical translation of polymer-drug conjugates for indications in dermatology and oncology. At extremely low doses, these formulations could save lives and improve the quality of life for patients undergoing treatment. I am looking to build strategic alliances with companies, and invite potential investors while identifying new unmet areas in the clinic for these drugs.
Northwest Building, B165
52 Oxford Street
Cambridge, MA 02138
Abhirup

Abhirup Mandal, PhD

Postdoctoral Fellow

The lack of understanding of ionic liquid (IL)-based formulations and drug delivery systems for biomolecules poses a hurdle to their future integration into the pharmaceutical sector. My research focuses on (1) developing a well-defined toolbox of solvent architectures for IL-based formulations; (2) discovering common & complimentary elements for ILs rational design; and (3) finely tuning IL-based platforms for delivering biomolecules across various biological barriers while preserving their biological activity for a prolonged period.

Northwest Building, B158
52 Oxford Street
Cambridge, MA 02138