M Zakrewsky, A Banerjee, S Apte, T Kern, MR Jones, RE Del Sesto, A Kopposch, DT Fox, and S Mitragotri. 2016. “Choline and geranate deep eutectic solvent as a Broad-Spectrum Antiseptic Agent for Preventive and Therapeutic Applications.” Advanced Healthcare Materials, 5, 11, Pp. 1282-1289.
K Camacho, S Menegatti, D Vogus, A Pusluri, Z Fuchs, M Jarvis, M Zakrewsky, M Evans, and S Mitragotri. 2016. “DAFODIL: A novel liposome-encapsulated synergistic combination of doxorubicin and 5FU for low dose chemotherapy.” Journal of Controlled Release, 229, Pp. 154-162.
S Menegatti, M Zakrewsky, S Kumar, J Oliveira, JA Muraski, and S Mitragotri. 2016. “De novo Design of Skin-penetrating Peptides for Enhanced Transdermal Delivery of Peptide Drugs.” Advanced Healthcare Materials, 5, 5, Pp. 602-609.
V Gupta, BH Hwang, N Doshi, A Banerjee, AC Anselmo, and S Mitragotri. 2016. “Delivery of Exenatide and Insulin Using Mucoadhesive Intestinal Devices.” Annals of Biomedical Eng., Annals of Biomedical Engineering, 44, 6, Pp. 1993-2007.
D Pan, B. Zern O Vargas-Morales, AC Anselmo, V Gupta, M Zakrewsky, S Mitragotri, and V Muzykantov. 2016. “The Effect of Polymeric Nanoparticles on Biocompatibility of Carrier Red Blood Cells.” PloS one, 11, 3, Pp. e0152074.
M Zakrewsky, JA Muraski, and S Mitragotri. 2016. “Energy-Dependent Internalization of SPACETM Peptide for Rapid Drug Delivery into the Cytoplasm of Human Epidermal Keratinocytes”.
AC Anselmo and S Mitragotri. 2016. “Impact of Particle Elasticity on Particle-Based Drug Delivery Systems.” Advanced Drug Delivery Reviews.
A Banerjee, JH Lee, and S Mitragotri. 2016. “Intestinal Mucoadhesive Devices for Oral Delivery of Insulin”.
K Camacho, S Menegatti, and S Mitragotri. 2016. “Low-molecular-weight-Polymer-drug Conjugates for Synergistic Anticancer Activity of Camptothecin and Doxorubicin Combinations.” Nanomedicine, 11, 9, Pp. 1139-1151.
M Zakrewsky, JA Muraski, and S Mitragotri. 2016. “Mechanistic Analysis of Cellular Internalization of a Cell-and Skin-Penetrating Peptide.” Regenerative Engineering and Translational Medicine, 2, 1, Pp. 23-26.
J Myserson, AC Anselmo, Y Liu, S Mitragotri, D Eckmann, and V Muzykantov. 2016. “Non-affinity factors modulating vascular targeting of nano- and microcarriers.” Advanced Drug Delivery Reviews, 99, PartA, Pp. 97-112.
C Villa, AC Anselmo, S Mitragotri, and V Muzykantov. 2016. “Red blood cells: Supercarriers for drugs, biologicals, and nanoparticles and inspiration for advanced delivery systems”.
A Banerjee, J Qi, R Gogoi, J Wong, and S Mitragotri. 2016. “Role of nanoparticle size, shape and surface chemistry in oral drug delivery.” Journal of Controlled Release, 238, Pp. 176-185.
Michael Zakrewsky and Samir Mitragotri. 2016. “Therapeutic RNAi robed with ionic liquid moieties as a simple, scalable prodrug platform for treating skin disease.” J Control Release, 242, Pp. 80-88.Abstract
The high prevalence of skin diseases and their visible symptoms result in major physical, emotional, and economic burden for which few solutions exist. To address this unmet medical need, topical delivery of RNAi such as siRNA holds many advantages including direct access to the diseased site, potent knockdown of disease symptoms, and limited off-target effects. Unfortunately, delivering drugs into skin is extremely difficult. To address these concerns, we present RNAi robed with ionic liquid moieties. Specifically, we show that robed-siRNAs can be synthesized by a simple two-step process from bulk materials. Robing affords tuneability of properties necessary for dermal drug delivery including octanol-water partitioning, skin transport, and cell internalization. The efficacy and safety of robed-siRNA for treating skin disease was confirmed by its ability to limit breakdown of elastin, a major cause of premature aging, following UVB exposure to human reconstructed skin tissue. Together, the data strongly support that therapeutic RNAi robed with ionic liquid moieties are a simple, scalable prodrug platform for treating skin disease.
S Mitragotri, DG Anderson, X Chen, EK Chow, D Ho, AV Kabanov, JM Karp, K Kataoka, CA Mirkin, SH Petrosko, J Shi, MM Stevens, S Sun, S Teoh, SS Venkatraman, Y Xia, S Wang, Z Gu, and C Xu. 2015. “Accelerating the Translation of Nanomaterials in Biomedicine.” ACS Nano, 9, 7, Pp. 6644-6654.
A Anselmo and S Mitragotri. 2015. “Biomimetic Engineering of Particles: Synthetic Cells.” Indian CRS Newsletter.
AC Anselmo, M Zhang, S Kumar, DR Vogus, S Menegatti, and ME Helgeson et al. 2015. “Elasticity of Nanoparticles Influences Their Blood Circulation, Phagocytosis, Endocytosis and Targeting.” ACS Nano, 9, 3, Pp. 3169-3177.
S Kumar, M Chen, AC Anselmo, JA Muraski, and S Mitragotri. 2015. “Enhanced epidermal localization of topically applied steroids using SPACE™ peptide.” Drug delivery and translational research, 5, 5, Pp. 523-530.
AC Anselmo, S Kumar, V Gupta, AM Pearce, A Ragusa, V Muzykantov, and S Mitragotri. 2015. “Exploiting Shape, Cellular-Hitchhiking and Antibodies to Target Nanoparticles to Lung Endothelium: Synergy Between Physical, Chemical and Biological Approaches.” Biomaterials, 68, Pp. 1-8.
K Aoyagi, M Zakrewsky, and S Mitragotri. 2015. “Formulating propranolol as an amorphous melt affords reduced skin irritation potential for transdermal drug delivery.” Technology, 3, 4, Pp. 214-238.