Publications

2016
A Banerjee, J Qi, R Gogoi, J Wong, and S Mitragotri. 2016. “Role of nanoparticle size, shape and surface chemistry in oral drug delivery.” Journal of Controlled Release, 238, Pp. 176-185.
Michael Zakrewsky and Samir Mitragotri. 2016. “Therapeutic RNAi robed with ionic liquid moieties as a simple, scalable prodrug platform for treating skin disease.” J Control Release, 242, Pp. 80-88.Abstract
The high prevalence of skin diseases and their visible symptoms result in major physical, emotional, and economic burden for which few solutions exist. To address this unmet medical need, topical delivery of RNAi such as siRNA holds many advantages including direct access to the diseased site, potent knockdown of disease symptoms, and limited off-target effects. Unfortunately, delivering drugs into skin is extremely difficult. To address these concerns, we present RNAi robed with ionic liquid moieties. Specifically, we show that robed-siRNAs can be synthesized by a simple two-step process from bulk materials. Robing affords tuneability of properties necessary for dermal drug delivery including octanol-water partitioning, skin transport, and cell internalization. The efficacy and safety of robed-siRNA for treating skin disease was confirmed by its ability to limit breakdown of elastin, a major cause of premature aging, following UVB exposure to human reconstructed skin tissue. Together, the data strongly support that therapeutic RNAi robed with ionic liquid moieties are a simple, scalable prodrug platform for treating skin disease.
2015
S Mitragotri, DG Anderson, X Chen, EK Chow, D Ho, AV Kabanov, JM Karp, K Kataoka, CA Mirkin, SH Petrosko, J Shi, MM Stevens, S Sun, S Teoh, SS Venkatraman, Y Xia, S Wang, Z Gu, and C Xu. 2015. “Accelerating the Translation of Nanomaterials in Biomedicine.” ACS Nano, 9, 7, Pp. 6644-6654.
A Anselmo and S Mitragotri. 2015. “Biomimetic Engineering of Particles: Synthetic Cells.” Indian CRS Newsletter.
AC Anselmo, M Zhang, S Kumar, DR Vogus, S Menegatti, and ME Helgeson et al. 2015. “Elasticity of Nanoparticles Influences Their Blood Circulation, Phagocytosis, Endocytosis and Targeting.” ACS Nano, 9, 3, Pp. 3169-3177.
S Kumar, M Chen, AC Anselmo, JA Muraski, and S Mitragotri. 2015. “Enhanced epidermal localization of topically applied steroids using SPACE™ peptide.” Drug delivery and translational research, 5, 5, Pp. 523-530.
AC Anselmo, S Kumar, V Gupta, AM Pearce, A Ragusa, V Muzykantov, and S Mitragotri. 2015. “Exploiting Shape, Cellular-Hitchhiking and Antibodies to Target Nanoparticles to Lung Endothelium: Synergy Between Physical, Chemical and Biological Approaches.” Biomaterials, 68, Pp. 1-8.
K Aoyagi, M Zakrewsky, and S Mitragotri. 2015. “Formulating propranolol as an amorphous melt affords reduced skin irritation potential for transdermal drug delivery.” Technology, 3, 4, Pp. 214-238.
K Aoyagi, M Zakrewsky, and S Mitragotri. 2015. “Formulating propranolol as an amorphous melt affords reduced skin irritation potential for transdermal drug delivery.” Technology, 3, 04, Pp. 1550010.
S Mitragotri and J Hanes. 2015. “Journal of Drug Delivery Life Time Achievement Award for Prof. Robert Lager.” Journal of Drug Targeting, 23, 7-8, Pp. 579.
AC Anselmo, JB Gilbert, S Kumar, V Gupta, RE Cohen, MF Rubner, and et al. 2015. “Monocyte-mediated delivery of polymeric backpacks to inflamed tissues: a generalized strategy to deliver drugs to treat inflammation.” Journal of Controlled Release, 199, Pp. 29-36.
JW Myerson, AC Anselmo, Y Liu, S Mitragotri, D Eckmann, and V Muzykantov. 2015. “Non-affinity factors modulating vascular targeting of nano- and microcarriers.” Advanced Drug Delivery Reviews, S0169-409X, 15, Pp. 00236-7.
M Zakrewsky, S Kumar, and S Mitragotri. 2015. “Nucleic acid delivery into skin for the treatment of skin disease: Proofs-of-concept, potential impact, and remaining challenges.” J Control Rel., 219, Pp. 445-456.
S Kumar, M Zakrewsky, M Chen, S Menegatti, JA Muraski, and S Mitragotri. 2015. “Peptides as skin penetration enhancers: Mechanisms of action.” Journal of Controlled Release, 199, Pp. 168-178.
AC Anselmo and S Mitragotri. 2015. “A Review of Clinical Translation of Inorganic Nanoparticles.” AAPS Journal, 17, 5, Pp. 1041-1054.
S Kumar, AC Anselmo, A Banerjee, and S Mitragotri. 2015. “Shape and size-dependent immune response to antigen-carrying nanoparticles.” J Control Rel., 220, Pt A, Pp. 141-148.
KM Camacho, S Kumar, S Menegatti, DR Vogus, AC Anselmo, and S Mitragotri. 2015. “Synergistic Antitumor Activity of Camptothecin-Doxorubicin Combinations and their Conjugates with Hyaluronic Acid.” Journal of Controlled Release, 210, Pp. 198-207.
S Menegatti, N Ruocco, S Kumar, M Zakrewsky, J Oliveira, ME Helgeson, LG Leal, and S Mitragotri. 2015. “Synthesis and characterization of a self-fluorescent hyaluronic acid-based gel for Dermal applications.” Advanced Healthcare Materials, 4, 15, Pp. 2297-2305.
M Chen, S Kumar, AC Anselmo, V Gupta, DH Slee, JA Muraski, and et al. 2015. “Topical delivery of Cyclosporine A into the skin using SPACE-peptide.” Journal of Controlled Release, 199, Pp. 190-197.
D Paithankar, BH Hwang, G Munavalli, A Kauvar, J Lloyd, and Blomgren R et al. 2015. “Ultrasonic delivery of silica–gold nanoshells for photothermolysis of sebaceous glands in humans: Nanotechnology from the bench to clinic.” Journal of Controlled Release, 206, Pp. 30-36.

Pages